Rosuvastatin for Primary Prevention Among Individuals With Elevated High-Sensitivity C-Reactive Protein and 5% to 10% and 10% to 20% 10-Year Risk

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Rosuvastatin for primary prevention among individuals with elevated high-sensitivity c-reactive protein and 5% to 10% and 10% to 20% 10-year risk. Implications of the Justification for Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial for "intermediate risk".

BACKGROUND Recent primary prevention guidelines issued in Canada endorse the use of statin therapy among individuals at "intermediate risk" who have elevated levels of high-sensitivity C-reactive protein (hsCRP). However, trial data directly addressing whether this recommendation defines a patient population in which statin therapy is effective have not previously been published. METHODS AND ...

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Rosuvastatin in patients with elevated C-reactive protein.

To the Editor: Ridker et al. (Nov. 20 issue) report the results of Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER),1 which showed that rosuvastatin significantly reduced cardiovascular events in patients with elevated levels of C-reactive protein. However, broad application of their results in primary prevention is premature, since the...

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ژورنال

عنوان ژورنال: Circulation: Cardiovascular Quality and Outcomes

سال: 2010

ISSN: 1941-7713,1941-7705

DOI: 10.1161/circoutcomes.110.938118